PACS Course Number 168
9 AM to 5 PM
This is a practical course covering the basic principles of photostability and photostability testing of drugs and other substances. It is designed for those new to the field as well as those with some experience. Fundamental concepts, practical applications, and regulatory aspects will be covered. The course director, Dr. John M. Allen, has an extensive background in photochemistry and photostability testing. He will help participants solve practical problems.
- Some major topics you will learn about in this one day course are:
- 1. Identification of substances that are likely to absorb light and undergo photoreactions resulting in poor photostability.
- 2. Practical approaches for perfoming drug photostability testing of drug substances in accordance with ICH guidelines
- 3. Evaluation, comparison, and selection of illumination sources used for photostability testing.
- 4. Practical approaches for actinometric (light dose) measurements during photostability testing
- 5. Specific approaches for dealing with photostability testing of solid drug samples (e.g,, tablets), powders, suspensions, liquid solutions, and other drug formulations.
- 6. Strategies for protection of drug samples and enhancement of photostability.
- 7. Participants are encouraged to bring with them actual photostability problems of general interest for discussion and development of strategies for solving these problems
PACS courses related to activated carbon are titled:
- Activated Carbon Adsorption Principles, GAED, Practices and Opportunities
- Selecting the Best Activated Carbon for a Specific Application
- Activated Carbon Production and Sales
- Certification Issues for Activated Carbon and Residential Activated Carbon Water Treatment Units
- Design, Operation, and Troubleshooting of Activated Carbon Liquid and Vapor Phase Systems
- BioMass to BioChar: Renewable Carbonaceous Products
- Agglomeration Technologies for Particle Enlargement
- A Primer on Coal: Energy and Environment
- Computational Fluid Dynamics (CFD) and Simulations for Industrial Problem Solving
- Pressure Swing Adsorption and other Cyclic Adsorption Processes and Applications
- Photostability of Pollutants, Drugs and Other Substances
Course Registration is available. You may also register through an associated conference registration. Send it with a payment of $2250 to secure your course attendance. Hotel information and a map will be sent to confirm your registration. Please list your special interest(s) on the registration form. Enrollment is limited to assure your maximum course benefits. On-site PACS courses are available (most PACS courses can be provided at your time and place). Telephone Henry Nowicki or Barb Sherman at 1.724.457.6576 if you need further information. PACS also provides laboratory testing and consulting services.
Photostability of Pollutants, Drugs and Other Substances
Course Instructor: Dr. John Allen under the auspices of PACS
Overview of drug photostability and photostability testing
- Practical and Theoretical Principles
Absorption of electromagnetic radiation (EMR) by drug molecules
Direct sunlight, window-filtered sunlight, and room light spectral energy distributions
Effects of molecular structure on photostability: Functional groups that lead to poor photostability
Photoreactions: Photolysis, photorearrangement, and energy transfer
Effects of reactions involving photochemically generated transient intermediates on drug photostability and the importance of oxygen
- Compliance with ICH Guidelines for Photostability Testing of Drug Substances
Light source options 1 and 2: Which option is best?Assessment and selection of commercially available photostability testing chambers
Forced degradation and confirmatory testing
Sample presentation: solid tablets, powders, suspensions, and liquid solutions
Some issues associated with capsules: the importance of humidity control during photostability testing
Selection of sample containers for photostability testing
The importance of proper sample placement in photostability chambers
Problems resulting from poor temperature control
Analytical procedures for assessing photostability
Use of radiometers
Avoiding serious difficulties with chemical actinometry when using quinine
- Strategies for Improvement of Drug Photostability
Titanium dioxide coating of tablets
Proper choice of formulation excipients and drug photostability
The use of photostabilizing excipients in formulations
This course introduces participants to the basic principles underlying drug photostability and to the practical aspects of drug photostability testing in accordance with ICH guidelines. Participants are encouraged to bring with them specific problems for evaluation and discussion.
Course participants are encouraged to e-mail questions to Dr. Henry Nowicki at Henry@pacslabs.com
Please list your special interest during registration. We will try to accommodate your interest.
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