Professional Analytical and Consulting Services

Toxicology Basic Principles

PACS Course Number 110

9 AM to 5 PM

An understanding of the basic principles of toxicology is critical for effective environmental management. Laws and regulations use toxicological principles as their basis - SDWA, RCRA, CERCLA/SARA, TSCA, OSHA Laboratory Standard and air and water regulations. This course is designed for chemical hygiene officers, managers, lawyers, engineers and chemists who need a short course because they now find themselves with the need to know. The course agenda is shown below. The course manual is available for those not able to attend.

This intensive course has been specially designed with practical and concise information for specialists without any previous training in toxicology principles. In one day's time, you will receive the necessary information for developing an understanding of toxicology and how its concepts are applied to industrial safety and personal health protection as well as environmental compliance program development. You'll leave with an expanded and useful toxicology vocabulary and develop an awareness of the use of toxicology considerations in making smart management decisions. This information will be especially valuable as you progress into more complex environmental compliance problems such as risk assessment and risk management strategies.

Register by mailing a copy of the REGISTRATION FORM. Send it with a payment of $795 to secure your attendance. Hotel information and a map will be sent to confirm your registration. Please list your special interest(s) on the registration form. Enrollment is limited to assure your maximum course benefits. On-site PACS courses are available (most PACS courses can be provided at your time and place). Telephone Henry Nowicki or Barb Sherman at 1.724.457.6576 if you need further information. PACS also provides laboratory testing and consulting services.

Toxicology Basic Principles

Course Instructor: Dr. Henry Nowicki

General topics
Introduction: Purpose and scope of the course; Fundamental concepts of toxicology; Defining and Understanding Toxicology Terms
Toxicity Assessment: Research; Data; Quantitative Indices; Margin of Safety; Toxic Level; Species Variations
Exposure Assessment: Site characteristics; Sampling/analysis; Affected populations; Exposure level
Risk Assessment: Putting together the toxicity and the exposure
Dose-Response Curves: Uses and shapes; Lowest-Adverse-Effect-Level(LOAEL); TD₅₀, TD₁₀₀
Endpoints: Criterion for selection of endpoints; Common endpoints and measuring techniques
Threshold and No Threshold Chemicals: Chemicals with thresholds and determination of threshold values; Chemicals without thresholds
Extrapolations from High to Low Doses: Animal experiments; Mathematical models(doses-response models)
Protocols Used in Toxicology: Studies in laboratory animals; Clinical studies in humans; Epidemiological studies; Exctoxicological studies
Acute/Subchronic/Chronic Studies
Data Validation: Confounding factors; Bias; Data analysis
Compound Lists and Drug Testing
Summaries of Toxicological Information: Dioxins, Furans, TCE, Lead

PACS offers the course manual separately if unable to attend

View the PACS Short Course Schedule

Course participants are encouraged to e-mail questions to Dr. Henry Nowicki at

Please NOTE: List your special interest on the registration form. We will try to accommodate your interest. PACS also provides internet consulting information at http://pacslabs.com

Training is an Investment in employee employer Future!

For more information please contact:

Henry Nowicki, Ph.D. / M.B.A
PACS Testing, Consulting and Training
409 Meade Drive, Coraopolis, PA 15108
Phone: 1. 724. 457. 6576 or 1. 800. 367. 2587
Fax: 1. 724. 457. 1214
E-Mail:
PACS website: http://pacslabs.com

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