Professional Analytical and Consulting Services

Toxicology Basic Principles

PACS Course Number 110

9 AM to 5 PM

An understanding of the basic principles of toxicology is critical for effective environmental management. Laws and regulations use toxicological principles as their basis - SDWA, RCRA, CERCLA/SARA, TSCA, OSHA Laboratory Standard and air and water regulations. This course is designed for chemical hygiene officers, managers, lawyers, engineers and chemists who need a short course because they now find themselves with the need to know. The course agenda is shown below. The course manual is available for those not able to attend.

This intensive course has been specially designed with practical and concise information for specialists without any previous training in toxicology principles. In one day's time, you will receive the necessary information for developing an understanding of toxicology and how its concepts are applied to industrial safety and personal health protection as well as environmental compliance program development. You'll leave with an expanded and useful toxicology vocabulary and develop an awareness of the use of toxicology considerations in making smart management decisions. This information will be especially valuable as you progress into more complex environmental compliance problems such as risk assessment and risk management strategies.

Register by mailing a copy of the REGISTRATION FORM. Send it with a payment of $995 to secure your attendance. Hotel information and a map will be sent to confirm your registration. Please list your special interest(s) on the registration form. Enrollment is limited to assure your maximum course benefits. On-site PACS courses are available (most PACS courses can be provided at your time and place). Telephone Henry Nowicki or Barb Sherman at 1.724.457.6576 if you need further information. PACS also provides laboratory testing and consulting services.



Toxicology Basic Principles

Course Instructor: Dr. Henry Nowicki

General topics
Introduction
Purpose and scope of the course
Fundamental concepts of toxicology
Defining and Understanding Toxicology Terms
Toxicity Assessment
Research
Data
Quantitative Indices
Margin of Safety
Toxic Level
Species Variations
Exposure Assessment
Site characteristics
Sampling/analysis
Affected populations
Exposure level
Risk Assessment
Putting together the toxicity and the exposure
Dose-Response Curves
Uses and shapes
Lowest-Adverse-Effect-Level(LOAEL)
TD50, TD100
Endpoints
Criterion for selection of endpoints
Common endpoints and measuring techniques
Threshold and No Threshold Chemicals
Chemicals with thresholds and determination of threshold values
Chemicals without thresholds
Extrapolations from High to Low Doses
Animal experiments
Mathematical models(doses-response models)
Protocols Used in Toxicology
Studies in laboratory animals
Clinical studies in humans
Epidemiological studies
Exctoxicological studies
Acute/Subchronic/Chronic Studies
Data Validation
Confounding factors
Bias
Data analysis
Compound Lists and Drug Testing
Summaries of Toxicological Information
Dioxins, Furans, TCE, Lead

PACS offers the course manual separately if unable to attend

View the PACS Short Course Schedule

Course participants are encouraged to e-mail questions to Dr. Henry Nowicki at

Please NOTE: List your special interest on the registration form. We will try to accommodate your interest. PACS also provides internet consulting information at http://pacslabs.com

Training is an Investment in employee employer Future!

For more information please contact:

Henry Nowicki, Ph.D. / M.B.A
PACS Testing, Consulting and Training
409 Meade Drive, Coraopolis, PA 15108
Phone: 1. 724. 457. 6576 or 1. 800. 367. 2587
E-Mail:
PACS website: http://pacslabs.com


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